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#Microglia

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Albert Cardona

@eLife

Nice video of neuronal activity!

"Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice"
Nebeling et al. 2023 elifesciences.org/articles/831

Editor evaluation: "This work provides insights into the use of anesthetics in measuring cellular dynamics, regional differences in plasticity, and neuronal activity regulation of microglia dynamics. It is an important contribution to understanding hippocampal microglia plasticity in adulthood."

eLifeMicroglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake miceMicroglia that presumably sense neuronal activity via detection of glutamate at synapses in the hippocampus show higher fine process motility and increased contact rates associated with formation and elimination of dendritic spines under conditions of elevated neuronal activity.
#neuroscience#microglia#neurons
*
Liz Haynes 🐟🔬🧠

First #FluorescenceFriday toot. This is some content I'm not ready to put on the bird site for a wide audience, but here's a gif of a single z-stack of #microglia in a living adult (3 month old) #zebrafish brain. It's the new work I've been cooking up since I joined Morgridge Institute! There are a lot of challenges to imaging in the live brain that I'm still working through, but I'm excited to keep refining things!

Phil Rivera

#introduction

Hi everyone!

I am an Assistant Professor in the Dept. of Biology at #HopeCollege (#PUI). I study #Behavior and #Neuroimmunology in mice and humans. My research uses #drugs of abuse (i.e. #morphine and #alcohol) and #space radiation to probe how peripheral #immune responses impact #cognition . I #teach and #mentor #undergraduates (#STEM) how to think about #science and challenge them to question HOW they know content. Here are some other topics/tags that I am fond of: #drugsofabuse #spaceradiation #learningandmemory #adultneurogenesis #microglia #macrophage #mentalhealth

venlafaxino

Feeling quite excited about starting my PhD soon next month. I hope covid won't slow down my research too much!

The stuff is very interesting: when young neurons need help to grow and duplicate, #microglia migrate and extend their processes towards them. In this way they support the cell with nutrients and growth factors so that it can keep developing. #Glioma cells hijack this physiological mechanism for their own good and use it to keep growing uncontrollably, becoming lethal cancers. What's even more cool is how microglia manage to build a whole deep cellular network to make this happen. I'll probably spend a lot of time #imaging brains (well, zebrafish brains) and cells, which I always loved

Also, today is a special day: just got my first poop in my new flat + I'm getting a dog :blobblush:

Continued thread
eSagan 🇮🇳

**Glial Cells**
The human brain contains 86B neurons and 85B Glia.

**Different types of Glia:**

🔸 Astrocytes: Astrocytes are really important type of Glia. They're essentially responsible for keeping the environment clean, they're the sanitation worker of the brain. So they are picking up all the refuse that the neurons have let loose including excess ions, excess #neurotransmitters and their metabolites.

They also are very important during development. They allow neurons to get to where they have to go during development. #Neurons are born in one place and they have to go some place else, and what highway did they take? They hitch on a progenitor cell that is going to become an #Astrocyte.

And, in addition when synapses are formed, the synapses are not maintained without some effort, and part of that is that the synapses are enveloped in the processes of #Astrocytes. So, there's a lot of structural and metabolic support that the Astrocytes are providing for neurons.

🔸 Oligodendrocytes and Schwann Cells: The #oligodendrocytes make myelin in the CNS and the #SchwannCells make it in the Peripheral Nervous System. So all these demyelinating diseases will affect either central myelin or peripheral #myelin. They will not affect both -- central or peripheral.

Because they are made by two different types. The Oligodendrocytes in the central nervous system and a Schwann cells in the peripheral nervous system.

🔸 Microglia: #Microglia are the one exception to the rule that
nervous system, that the cells of the nervous system come from Ectoderm. These are actually essentially immune cells coming from the blood lineage. These are immune cells that have invaded into the central nervous system and their job is to be quiet. And if we're healthy and everything goes well, they are quiet. But when there is a problem these microglia react, they try to rectify things, they try and bring some attention to areas of damage and what is emerging is that sometimes they go overboard and they start to participate in making the problem as well as solving the problem.

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