101010.pl

Fabrizio Musacchio📢 Our new study is now published in Communications Biology (Nature Portfolio): We demonstrate deep in vivo <a href="https://sigmoid.social/tags/ThreePhoton" class="mention hashtag" rel="nofollow noopener" target="_blank">#ThreePhoton</a> imaging 🔬 of neurons 🧠 and glia in the medial prefrontal cortex with subcellular resolution!👉 <a href="https://www.nature.com/articles/s42003-025-08079-8" rel="nofollow noopener" translate="no" target="_blank">https://www.nature.com/articles/s42003-025-08079-8</a><a href="https://sigmoid.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#Neuroscience</a> <a href="https://sigmoid.social/tags/Microscopy" class="mention hashtag" rel="nofollow noopener" target="_blank">#Microscopy</a> <a href="https://sigmoid.social/tags/CalciumImaging" class="mention hashtag" rel="nofollow noopener" target="_blank">#CalciumImaging</a> <a href="https://sigmoid.social/tags/Microglia" class="mention hashtag" rel="nofollow noopener" target="_blank">#Microglia</a> <a href="https://sigmoid.social/tags/DZNE" class="mention hashtag" rel="nofollow noopener" target="_blank">#DZNE</a> <a href="https://social.bund.de/@dzne" class="u-url mention" rel="nofollow noopener" target="_blank">@dzne</a>

Albert Cardona<a href="https://fediscience.org/@eLife" class="u-url mention" rel="nofollow noopener" target="_blank">@eLife</a>Nice video of neuronal activity!"Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice" Nebeling et al. 2023 <a href="https://elifesciences.org/articles/83176" rel="nofollow noopener" target="_blank">https://elifesciences.org/articles/83176</a>Editor evaluation: "This work provides insights into the use of anesthetics in measuring cellular dynamics, regional differences in plasticity, and neuronal activity regulation of microglia dynamics. It is an important contribution to understanding hippocampal microglia plasticity in adulthood."<a href="https://mathstodon.xyz/tags/neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#neuroscience</a> <a href="https://mathstodon.xyz/tags/microglia" class="mention hashtag" rel="nofollow noopener" target="_blank">#microglia</a> <a href="https://mathstodon.xyz/tags/neurons" class="mention hashtag" rel="nofollow noopener" target="_blank">#neurons</a> <a href="https://mathstodon.xyz/tags/mouse" class="mention hashtag" rel="nofollow noopener" target="_blank">#mouse</a> <a href="https://mathstodon.xyz/tags/hippocampus" class="mention hashtag" rel="nofollow noopener" target="_blank">#hippocampus</a>

Joe SabatinoReally provocative new study on <a href="https://fediscience.org/tags/myelin" class="mention hashtag" rel="nofollow noopener" target="_blank">#myelin</a> changes in normal appearing white matter in <a href="https://fediscience.org/tags/multiplesclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#multiplesclerosis</a> with increased <a href="https://fediscience.org/tags/microglia" class="mention hashtag" rel="nofollow noopener" target="_blank">#microglia</a> activation and perivascular <a href="https://fediscience.org/tags/Tcell" class="mention hashtag" rel="nofollow noopener" target="_blank">#Tcell</a> accumulation<a href="https://onlinelibrary.wiley.com/doi/10.1002/ana.26585#.Y6yCz_Ef-EM.twitter" rel="nofollow noopener" target="_blank">https://onlinelibrary.wiley.com/doi/10.1002/ana.26585#.Y6yCz_Ef-EM.twitter</a>

Liz Haynes 🐟🔬🧠First <a href="https://fediscience.org/tags/FluorescenceFriday" class="mention hashtag" rel="nofollow noopener" target="_blank">#FluorescenceFriday</a> toot. This is some content I'm not ready to put on the bird site for a wide audience, but here's a gif of a single z-stack of <a href="https://fediscience.org/tags/microglia" class="mention hashtag" rel="nofollow noopener" target="_blank">#microglia</a> in a living adult (3 month old) <a href="https://fediscience.org/tags/zebrafish" class="mention hashtag" rel="nofollow noopener" target="_blank">#zebrafish</a> brain. It's the new work I've been cooking up since I joined Morgridge Institute! There are a lot of challenges to imaging in the live brain that I'm still working through, but I'm excited to keep refining things!

Yeonwoo Lebovitz, PhD<a href="https://qoto.org/tags/Introductions" class="mention hashtag" rel="nofollow noopener" target="_blank">#Introductions</a> I like and care about: <a href="https://qoto.org/tags/Microglia" class="mention hashtag" rel="nofollow noopener" target="_blank">#Microglia</a> <a href="https://qoto.org/tags/Microbiota" class="mention hashtag" rel="nofollow noopener" target="_blank">#Microbiota</a> <a href="https://qoto.org/tags/Neurodevelopment" class="mention hashtag" rel="nofollow noopener" target="_blank">#Neurodevelopment</a> <a href="https://qoto.org/tags/Neuroimmunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#Neuroimmunology</a> <a href="https://qoto.org/tags/GutBrainMicrobeAxis" class="mention hashtag" rel="nofollow noopener" target="_blank">#GutBrainMicrobeAxis</a> <a href="https://qoto.org/tags/GutBrainAxis" class="mention hashtag" rel="nofollow noopener" target="_blank">#GutBrainAxis</a> <a href="https://qoto.org/tags/SciencePolicy" class="mention hashtag" rel="nofollow noopener" target="_blank">#SciencePolicy</a> <a href="https://qoto.org/tags/RegulatoryScience" class="mention hashtag" rel="nofollow noopener" target="_blank">#RegulatoryScience</a> <a href="https://qoto.org/tags/RegulatoryPolicy" class="mention hashtag" rel="nofollow noopener" target="_blank">#RegulatoryPolicy</a> <a href="https://qoto.org/tags/TeaAndBiscotti" class="mention hashtag" rel="nofollow noopener" target="_blank">#TeaAndBiscotti</a> I am concerned about: <a href="https://qoto.org/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID</a> <a href="https://qoto.org/tags/LongCovid" class="mention hashtag" rel="nofollow noopener" target="_blank">#LongCovid</a>

Phil Rivera<a href="https://qoto.org/tags/introduction" class="mention hashtag" rel="nofollow noopener" target="_blank">#introduction</a> Hi everyone!I am an Assistant Professor in the Dept. of Biology at <a href="https://qoto.org/tags/HopeCollege" class="mention hashtag" rel="nofollow noopener" target="_blank">#HopeCollege</a> (<a href="https://qoto.org/tags/PUI" class="mention hashtag" rel="nofollow noopener" target="_blank">#PUI</a>). I study <a href="https://qoto.org/tags/Behavior" class="mention hashtag" rel="nofollow noopener" target="_blank">#Behavior</a> and <a href="https://qoto.org/tags/Neuroimmunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#Neuroimmunology</a> in mice and humans. My research uses <a href="https://qoto.org/tags/drugs" class="mention hashtag" rel="nofollow noopener" target="_blank">#drugs</a> of abuse (i.e. <a href="https://qoto.org/tags/morphine" class="mention hashtag" rel="nofollow noopener" target="_blank">#morphine</a> and <a href="https://qoto.org/tags/alcohol" class="mention hashtag" rel="nofollow noopener" target="_blank">#alcohol</a>) and <a href="https://qoto.org/tags/space" class="mention hashtag" rel="nofollow noopener" target="_blank">#space</a> radiation to probe how peripheral <a href="https://qoto.org/tags/immune" class="mention hashtag" rel="nofollow noopener" target="_blank">#immune</a> responses impact <a href="https://qoto.org/tags/cognition" class="mention hashtag" rel="nofollow noopener" target="_blank">#cognition</a> . I <a href="https://qoto.org/tags/teach" class="mention hashtag" rel="nofollow noopener" target="_blank">#teach</a> and <a href="https://qoto.org/tags/mentor" class="mention hashtag" rel="nofollow noopener" target="_blank">#mentor</a> <a href="https://qoto.org/tags/undergraduates" class="mention hashtag" rel="nofollow noopener" target="_blank">#undergraduates</a> (<a href="https://qoto.org/tags/STEM" class="mention hashtag" rel="nofollow noopener" target="_blank">#STEM</a>) how to think about <a href="https://qoto.org/tags/science" class="mention hashtag" rel="nofollow noopener" target="_blank">#science</a> and challenge them to question HOW they know content. Here are some other topics/tags that I am fond of: <a href="https://qoto.org/tags/drugsofabuse" class="mention hashtag" rel="nofollow noopener" target="_blank">#drugsofabuse</a> <a href="https://qoto.org/tags/spaceradiation" class="mention hashtag" rel="nofollow noopener" target="_blank">#spaceradiation</a> <a href="https://qoto.org/tags/learningandmemory" class="mention hashtag" rel="nofollow noopener" target="_blank">#learningandmemory</a> <a href="https://qoto.org/tags/adultneurogenesis" class="mention hashtag" rel="nofollow noopener" target="_blank">#adultneurogenesis</a> <a href="https://qoto.org/tags/microglia" class="mention hashtag" rel="nofollow noopener" target="_blank">#microglia</a> <a href="https://qoto.org/tags/macrophage" class="mention hashtag" rel="nofollow noopener" target="_blank">#macrophage</a> <a href="https://qoto.org/tags/mentalhealth" class="mention hashtag" rel="nofollow noopener" target="_blank">#mentalhealth</a>

Simon McArthur<a href="https://qoto.org/tags/introduction" class="mention hashtag" rel="nofollow noopener" target="_blank">#introduction</a> Hi, I’m a neuropharmacologist working at <a href="https://qoto.org/tags/QMUL" class="mention hashtag" rel="nofollow noopener" target="_blank">#QMUL</a> in London, studying the role of the gut <a href="https://qoto.org/tags/microbiome" class="mention hashtag" rel="nofollow noopener" target="_blank">#microbiome</a> in regulating <a href="https://qoto.org/tags/brain" class="mention hashtag" rel="nofollow noopener" target="_blank">#brain</a> function in health and disease, with focus on <a href="https://qoto.org/tags/dementia" class="mention hashtag" rel="nofollow noopener" target="_blank">#dementia</a> and <a href="https://qoto.org/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener" target="_blank">#Alzheimers</a>. We’re particularly interested in gut microbial metabolites and their impact on the blood-brain barrier and <a href="https://qoto.org/tags/microglia" class="mention hashtag" rel="nofollow noopener" target="_blank">#microglia</a>Still on Twitter as well @DrSimonMcArthur until it finally all falls apart…Also: <a href="https://qoto.org/tags/LGBT" class="mention hashtag" rel="nofollow noopener" target="_blank">#LGBT</a> <a href="https://qoto.org/tags/ukpolitics" class="mention hashtag" rel="nofollow noopener" target="_blank">#ukpolitics</a>

venlafaxinoFeeling quite excited about starting my PhD soon next month. I hope covid won't slow down my research too much!The stuff is very interesting: when young neurons need help to grow and duplicate, <a href="https://qoto.org/tags/microglia" class="mention hashtag" rel="nofollow noopener" target="_blank">#microglia</a> migrate and extend their processes towards them. In this way they support the cell with nutrients and growth factors so that it can keep developing. <a href="https://qoto.org/tags/Glioma" class="mention hashtag" rel="nofollow noopener" target="_blank">#Glioma</a> cells hijack this physiological mechanism for their own good and use it to keep growing uncontrollably, becoming lethal cancers. What's even more cool is how microglia manage to build a whole deep cellular network to make this happen. I'll probably spend a lot of time <a href="https://qoto.org/tags/imaging" class="mention hashtag" rel="nofollow noopener" target="_blank">#imaging</a> brains (well, zebrafish brains) and cells, which I always lovedAlso, today is a special day: just got my first poop in my new flat + I'm getting a dog :blobblush:

eSagan 🇮🇳**Glial Cells** The human brain contains 86B neurons and 85B Glia.**Different types of Glia:**🔸 Astrocytes: Astrocytes are really important type of Glia. They're essentially responsible for keeping the environment clean, they're the sanitation worker of the brain. So they are picking up all the refuse that the neurons have let loose including excess ions, excess <a href="https://qoto.org/tags/neurotransmitters" class="mention hashtag" rel="nofollow noopener" target="_blank">#neurotransmitters</a> and their metabolites. They also are very important during development. They allow neurons to get to where they have to go during development. <a href="https://qoto.org/tags/Neurons" class="mention hashtag" rel="nofollow noopener" target="_blank">#Neurons</a> are born in one place and they have to go some place else, and what highway did they take? They hitch on a progenitor cell that is going to become an <a href="https://qoto.org/tags/Astrocyte" class="mention hashtag" rel="nofollow noopener" target="_blank">#Astrocyte</a>.And, in addition when synapses are formed, the synapses are not maintained without some effort, and part of that is that the synapses are enveloped in the processes of <a href="https://qoto.org/tags/Astrocytes" class="mention hashtag" rel="nofollow noopener" target="_blank">#Astrocytes</a>. So, there's a lot of structural and metabolic support that the Astrocytes are providing for neurons.🔸 Oligodendrocytes and Schwann Cells: The <a href="https://qoto.org/tags/oligodendrocytes" class="mention hashtag" rel="nofollow noopener" target="_blank">#oligodendrocytes</a> make myelin in the CNS and the <a href="https://qoto.org/tags/SchwannCells" class="mention hashtag" rel="nofollow noopener" target="_blank">#SchwannCells</a> make it in the Peripheral Nervous System. So all these demyelinating diseases will affect either central myelin or peripheral <a href="https://qoto.org/tags/myelin" class="mention hashtag" rel="nofollow noopener" target="_blank">#myelin</a>. They will not affect both -- central or peripheral.Because they are made by two different types. The Oligodendrocytes in the central nervous system and a Schwann cells in the peripheral nervous system.🔸 Microglia: <a href="https://qoto.org/tags/Microglia" class="mention hashtag" rel="nofollow noopener" target="_blank">#Microglia</a> are the one exception to the rule that nervous system, that the cells of the nervous system come from Ectoderm. These are actually essentially immune cells coming from the blood lineage. These are immune cells that have invaded into the central nervous system and their job is to be quiet. And if we're healthy and everything goes well, they are quiet. But when there is a problem these microglia react, they try to rectify things, they try and bring some attention to areas of damage and what is emerging is that sometimes they go overboard and they start to participate in making the problem as well as solving the problem.

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#Microglia