Scientists have found a new way to recreate inner ear hair cells in the lab to study hearing loss.
https://elifesciences.org/reviewed-preprints/106550?utm_source=mastodon&utm_medium=social&utm_campaign=organic_pr
#DevBio #CellBio

How did the animal body plan evolve?

This ‘fundamental’ study in Clytia sheds light on how Wnt3 coordinates both gene expression and planar cell polarity during axis formation, offering key insights into the origins of morphogenesis.
https://elifesciences.org/articles/104508?utm_source=mastodon&utm_medium=social&utm_campaign=organic
#DevBio

We are all set up at SDB.

Visit our table in the Miramar Ballroom to collect free giveaways from @Dev_journal and @the_node and find out more about Open Access publishing, grants, events and our support for the developmental biology community.

Authors of this #DevBio study, ranked fundamental, have included an ‘Ideas and Speculation’ section

They propose possible mechanistic explanations of their research on BMP4 mutations that contribute to vertebrate development.
https://elifesciences.org/reviewed-preprints/105018?utm_source=mastodon&utm_medium=social&utm_campaign=organic_assessment#s3a

Organoids derived from placental tissue can be used to study processes involving syncytiotrophoblasts – cells that contain billions of nuclei – in the placenta. #DevBio
https://elifesciences.org/reviewed-preprints/101170?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Cell Signalling: Not all dimers are equal

Disease-causing mutations in the signalling protein BMP4 impair its secretion, but only when it is made as a homodimer. #DevBio
https://elifesciences.org/articles/106980?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights

Unravelling a signalling pathway

A new study reveals the network of molecules recruited by the signalling protein FGF during lens development. #DevBio
https://elifesciences.org/digests/103615/unravelling-a-signaling-pathway?utm_source=mastodon&utm_medium=social&utm_campaign=organic

This study spotlights Meis2 as a key player in whisker follicle formation and shows that nerves aren’t needed to get things started. Some mysteries remain about how Meis2 works, but the imaging is ‘solid’ and the insights are sharp. #DevBio
https://elifesciences.org/articles/100854?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Flatworms, but make it high-res.

This new protocol combines tissue expansion + light-sheet microscopy to reveal planarian neural and muscle anatomy in 3D, at single-cell resolution. #Planaria #Microscopy #DevBio
https://elifesciences.org/articles/101103?utm_source=mastodon&utm_medium=social&utm_campaign=organic

As @the_node celebrates their 15 year anniversary this year, we want to collect feedback from you, our community, to ensure the Node is still relevant and useful.

If you’ve ever visited the Node to read, write or interact with the developmental and stem cell biology community, please spare five minutes to take their survey:

https://surveymonkey.com/r/7QHYQCW

Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway. #DevBio
https://elifesciences.org/articles/97268?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Research into #ReproductiveHealth has historically been overlooked, while issues shape everything from #fertility to demographic trends and healthcare disparities. Read the latest research that paves the way for advances worldwide in our new Special Issue. #DevBio #Medicine #CellBio
https://elifesciences.org/collections/f8cc6f3f/special-issue-reproductive-health?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Temperature matters:

"brain connectivity scales continuously across temperatures"

With impacts on brain function:

"developmental temperature does not alter odor encoding in first- and second-order neurons, but it shifts the specificity of connections onto third-order neurons that mediate innate behaviors."

From: "Impact of developmental temperature on neural growth, connectivity, and function", by Züfle et al. 2025 (Carlotta Martelli's lab)
https://www.science.org/doi/full/10.1126/sciadv.adp9587

Fun, accessible piece by John Wallingford on situs invertus and left-right asymmetry in development.

I don’t think I saw this posted on Masto already. Anyway it went up in Oct and I only just read it. #DevBio

https://nautil.us/the-anatomical-quirk-that-saved-dr-no-951705/

Highly-respected non-profit journals like @Dev_journal support scientific communities. Authors are proud to publish there.

But, when your paper is rejected by a glam journal, it is tempting to avoid re-review by sliding down commercial ecosystems

But wait! Look! Development say “we will also consider papers with reviewer reports from other journals.” Game changer!

Plus: rigorous and fair reviewing system that avoids excessive additional experiments.

https://journals.biologists.com/dev/article/151/23/dev204523/363248/Constructive-Critics-Development-s-approach-to

Patterning the mushroom body in the insect brain, the center for associative learning and memory that is modularly organized with spatially tiled dendrites of output neurons (MBONs) and axons of dopaminergic neurons (DANs):

"Slit regulates compartment-specific targeting of dendrites and axons in the Drosophila brain", Deng et al. 2024

Turns out same molecules are used, the Robo receptor and it's ligand Slit, that are used to pattern the nerve cord mediolaterally.

https://www.biorxiv.org/content/10.1101/2024.10.29.620851v1

Hi! I'm a bot that shares research papers in EvoDevo (or Evolutionary Developmental Biology).

Currently, I index a few journals in the field and post links to articles that were published recently, one per day.

Since my posts are set to “quiet public”, they don't appear on Mastodon's feeds or hashtags searches. So, please, boost the papers you find worth sharing!

Any feedback is welcome. Thanks :)

A study in fruit flies, assessed as fundamental by reviewers, investigates how concussions early in life affect #neurodegeneration later in life. #Neuroscience #DevBio https://elifesciences.org/articles/97908?utm_source=mastodon&utm_medium=social&utm_campaign=organic

‪
Our latest preprint:

It is very useful to be able to measure the properties of individual cells in relation to their neighbours in 3D tissues, but it is also complicated & difficult

The talented Matt French devised computational approaches that helped us overcome many of these difficulties

This helps us work out when where & how cells make differentiation decisions by talking to their neighbours during axis elongation

Hope it's useful! Comments welcome

#DevBio

https://www.biorxiv.org/content/10.1101/2024.09.03.610492v1

Tenure-track group leader positions open at King's College London in "developmental neuroscience, defined broadly."
https://devneuro.org/cdn/content/pdf/TTGL_Sept24.pdf

Deadline is 23:59 BST on 25th September 2024.