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#sarscov2

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»Schwere Stürze gab es bisher kaum. Stattdessen zieht sich ein anderes Muster durch die offiziellen Mitteilungen der Teams – eine mysteriöse Krankheit.«

Wie häufig wurde #Corona, #SARSCoV2 oder #COVID19 im Artikel erwähnt?

radsportaktuell.de/radsport/kr

Krankheitswelle erschüttert Vuelta 2025
Radsportaktuell.de · Krankheitswelle erschüttert Vuelta 2025By Pascal Michiels

"A growing number of scientists believe that the SARS-CoV-2 virus may instead be subtly altering our immune systems. If correct, their hypothesis will change how we understand everything from respiratory syncytial virus (RSV) to shingles to sepsis."

God damn, finally.

bmj.com/content/390/bmj.r1733

The BMJ · Why scientists are rethinking the immune effects of SARS-CoV-2“Immunity debt,” a theory to explain the global surge in non-covid infections since pandemic restrictions were lifted, is increasingly being challenged by emerging evidence. Nick Tsergas reports Mycoplasma pneumoniae is a bacterial infection not known to cause widespread hospital admissions. “I can count on my two hands the number of times I’d ever seen mycoplasma pneumoniae before 2023,” says Samira Jeimy, clinical immunologist at the University of Western Ontario. “All of a sudden I feel like everybody has it.”1 Over the past three years similar reports have circulated of rising bacterial infections, flare-ups of old viruses becoming more common, and children landing in hospital with diseases not usually seen in young, healthy people. One explanation offered by public health leaders has been “immunity debt”2—the idea that precautions taken in the covid pandemic suppressed routine exposures to circulating pathogens, leaving people more vulnerable to them when restrictions were lifted. The theory landed in the public consciousness at the right moment. A simple idea that sounded like science, it soothed a public seeking answers just as the world was returning to a semblance of normality. And it served a policy function, allowing governments to focus on economic recovery. But its explanatory power has faded as the number of non-covid infections has kept rising each year. A 2024 analysis by the US Centers for Disease Control and Prevention3 found that invasive group A strep infections saw their most dramatic year-on-year increase from 2021 to 2022, well after most precautions had been lifted in the US. Rates have been abnormally high since then, raising questions about what might be behind the trend. A growing number of scientists believe that the SARS-CoV-2 virus may instead be subtly altering our immune systems. If correct, their hypothesis will change how we understand everything …

A recent common cold may nearly halve risk of COVID-19, study suggests

So Covid-Competent folks - this is going to land different in different quarters.

  • The previously evidence-supported paradigm/metaphor "the immune system is a candle not a muscle" might need to be abandoned for a third, more nuanced position[+]
  • Of course there's the need to check the paper itself, and if it's solid, to replicate / validate, but beyond that.
  • Folks with immune dysregulation can't all just catch rhinoviruses all the time to keep the system active.

[+] probably approximately: "microbes vary:

  • some are overwhelmingly beneficial, eg. in our gut;
  • some have mixed costs and benefits like rhinovirus or conditions when they become pathological like candida, and
  • some basically only have costs like influenza(?), SARS1 and SARS2, measles"

re: cidrap.umn.edu/covid-19/recent

www.cidrap.umn.eduA recent common cold may nearly halve risk of COVID-19, study suggestsAmong COVID-infected participants, recent rhinovirus infection was tied to a 9.6-fold lower SARS-CoV-2 viral load, or amount of virus in the body. 

From Canada:
"the high prevalence of new-onset chronic symptoms in the latter stages of the pandemic is concerning, especially considering that most infections occurred post-vaccination"

bmjopen.bmj.com/content/15/7/e

Screenshot from latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

New US press release:

Risk of #longCOVID increases with social and economic hardship: investigators led a nationwide study that found that financial hardship, food insecurity, lack of healthcare access, & other social risk factors are linked to higher risks of long #COVID

eurekalert.org/news-releases/1

Hashtags:
@longcovid #PASC #PwLC #postcovid #postcovid19 #Covidlonghaulers #PostCovidSyndrome #COVIDBrain
@covid19 #Coronavirus
#COVID19 #COVID #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe
@auscovid19

hey Covid-Competent, well-informed folks! I have a favour to ask!

has anyone bookmarked a good reference for what % of SARS-CoV-2 cases are due to fomite transmission?

the US CDC was at one point saying:

each contact with a contaminated surface has less than a 1 in 10,000 chance of causing an infection [1]

but that's not a % of infections, it's per contact with contaminated surface. That's supported a few ways, eg. by a sampling that included counting touchpoints:

The estimated risk of infection from touching a contaminated surface was low (less than 5 in 10,000) by quantitative microbial risk assessment [2]

but that study didn't actually culture virus, they checked RNA levels and counted touches (and again, is per contaminated touch, not per case)

Try as I might, I can't actually find a grounded estimate of how many actual infections have been fomite-driven at any point in the SARS-CoV-2 pandemic.

[1] archive.cdc.gov/www_cdc_gov/co
[2] pmc.ncbi.nlm.nih.gov/articles/

@askazero

Centers for Disease Control and Prevention · Coronavirus Disease 2019 (COVID-19)By CDC

More evidence of brain damage from mild COVID-19. Previous studies tested metabolic or electrical activity separately; this one tested both together.

They found both lower metabolism and slower neuron firing in the same brain areas of people with Long COVID.

significant hypometabolism in the bilateral frontal, temporal, and parietal lobes, as well as in the left occipital lobe, along with predominantly frontal EEG slowing in post-COVID-19 patients compared to healthy controls

the functional impact on memory was very strong:

a high incidence of subjective memory decline: 52.9% of post-COVID-19 patients scored more than 1.5 standard deviations [worse than] the normative sample on both the prospective and retrospective memory scales.

1.5 standard deviations is HUGE. That means that in a room of 101 people, lined up from best to worst memory, if person 51 in the middle gets unlucky with Long COVID, they would expect to end up with the 7th worst memory in the room. From literally average to under the bottom 10%!

Both hypometabolism and changes in spectral power are indicators of underlying neuronal stress or damage

nature.com/articles/s41598-025

discussed by:
mastodon.social/@MEActNOW/1147
kolektiva.social/@anarchademic
disabled.social/@tomkindlon/11
mastodonapp.uk/@PaulSchleifer/

NatureMapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing - Scientific ReportsCognitive decline is a common symptom of post-COVID-19 syndrome. However, the mechanisms underlying this deficit remain poorly understood. This study aims to investigate the relationship between brain metabolic and neurophysiological alteration patterns in patients with persistent subjective cognitive decline after mild COVID-19 using joint FDG-PET and EEG analyses. The study was conducted on 28 post-COVID-19 patients with cognitive decline, who underwent comprehensive clinical evaluation including cognitive testing, FDG-PET imaging, and EEG acquisition. Voxelwise statistical analysis of PET images was performed by comparing post-COVID-19 patients with healthy controls (p-voxel < 0.005 uncorrected, p-cluster < 0.005 FWE-corrected, K > 599 voxels). EEG spectral powers were extracted and compared with age and sex-matched controls. The results showed significant hypometabolism in the bilateral frontal, temporal, and parietal lobes, as well as in the left occipital lobe, along with predominantly frontal EEG slowing in post-COVID-19 patients compared to healthy controls. In particular, the EEG alterations were characterized by a significant increase in relative power in the delta and theta bands, accompanied by a marked reduction in alpha band power in the frontal, temporal, and central regions. The observed PET hypometabolism and EEG slowing patterns in anterior brain regions, may help to elucidate the pathophysiological mechanisms underlying cognitive decline in post-COVID-19 patients.

In France, ONE IN SEVEN kids with symptomatic COVID-19 developed Long COVID!

These are kids who had COVID-19 once!

Of 27,537 children diagnosed with acute COVID-19, 3,888 (14.1%) developed long COVID;

93.5% had pharmacy usage, and 61.0% had medical procedures

Children who had a COVID-19 reinfection prior to their long COVID diagnosis were excluded from the study

tandfonline.com/doi/abs/10.108

via disabled.social/@tomkindlon/11 h/t @tomkindlon

'Variant NB.1.8.1 is a product of intricate evolutionary events, its spread will further complicate prediction about future evolution & spreading trend of COVID, highlighting the importance & necessity of performing genomic surveillance & monitoring of #SARSCoV2 evolution'. 🔗@tactnowinfo.bsky.social

'COVID Update: COVID Cases Rising Worldwide: Inside the NB.1.8.1 (Nimbus) vs. XFG (Stratus) Variant Battle, by TACT.'
open.substack.com/pub/tactnowi

T.A.C.T. · COVID Update: COVID Cases Rising Worldwide: Inside the NB.1.8.1 (Nimbus) vs. XFG (Stratus) Variant BattleBy TACT

In 1987 volunteers were exposed to rhinovirus ("common cold") either by sharing air, or by sharing heavily contaminated objects.[2]

Most of the people who shared air with an infected person got sick.

None of the people who handled the heavily contaminated objects (and touched their faces!) got sick. And:

5/8 donor hands yielded culturable RV-A16 virus, while none of the recipient’s hands did [1]

[1] virologydownunder.com/rhinovir
[2] ncbi.nlm.nih.gov/pubmed/?term=

h/t mastodon.social/@mackayim2022 via mastodon.social/@mackayim2022/

Virology Down Under · Rhinovirus (RV) transmission by aerosol: does it happen or is transmission solely by hand-contact and self-inoculation?This study set out to determine whether rhinoviruses were transmitted by aerosol, indirect contact, or both.