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#CoV

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There is strong evidence of brain-related abnormalities in COVID-19.

However, it remains unknown whether the impact of #SARS-#CoV-2 infection can be detected in milder cases,
and whether this can reveal possible mechanisms contributing to brain #pathology.

Here we investigated #brain #changes in 785 participants of UK Biobank (aged 51–81 years) who were imaged twice using magnetic resonance imaging,

including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans
—with 141 days on average separating their diagnosis and the second scan
—as well as 384 controls.

The availability of pre-infection imaging data reduces the likelihood of pre-existing risk factors being misinterpreted as disease effects.

We identified significant longitudinal effects when comparing the two groups, including

(1) a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus;

(2) greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and

(3) a greater reduction in global brain size in the SARS-CoV-2 cases.

The participants who were infected with SARS-CoV-2 also showed on average a greater cognitive decline between the two time points.

Importantly, these imaging and cognitive longitudinal effects were still observed after excluding the 15 patients who had been hospitalised.

These mainly limbic brain imaging results may be the in vivo hallmarks of a degenerative spread of the disease through olfactory pathways,
of neuroinflammatory events,
or of the loss of sensory input due to anosmia.

Whether this deleterious effect can be partially reversed, or whether these effects will persist in the long term, remains to be investigated with additional follow-up.

nature.com/articles/s41586-022

NatureSARS-CoV-2 is associated with changes in brain structure in UK Biobank - NatureAfter infection with SARS-CoV-2, individuals show a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus; greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and a greater reduction in global brain size.

New (as yet unpublished) potential evidence that #SARS-#CoV-2 was found in #raccoon #dogs (canids) in the #Huanan #Market in late-2019. Specifically, viral and raccoon dog #DNA in #swabs presumably taken at the time from a stall known to house those animals.

Caveats:

-not yet #peer #reviewed.

-lots of DNA mixing together in a market.

-can the #provenance of the data be #verified?

- #zoonotic/#lab/market #origin are not #mutually #exclusive.

#COVID 🦠 🧬

🔗 theatlantic.com/science/archiv

Today's UK #CoV numbers are that we're growing by about 35% a day which is a bit grim. We managed 5779 tests yesterday of which 676 came back positive; so the test count is going up a lot (it was about 2000, but still way short of the 10k they were promising last week); but the fact such a high % is coming back positive suggests they're mostly testing people they thing has it.