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@uni_matrix Sounds like a plan. Now only need funding and willing new lab members :)
On amphibians, though: Briggman's lab is imaging the Xenopus tropicalis froglet. An excellent choice.
#connectomics #neuroscience
Joergen Kornfeld just opened his lab at the #MRCLMB – he is now our colleague!
His lab is recruiting students, postdocs, and staff scientists. Reach out to Joergen directly.
https://www2.mrc-lmb.cam.ac.uk/group-leaders/h-to-m/joergen-kornfeld/
Indeed – and functional imaging is much less than half the story too. Without transcriptomics we are all flying blind. And without theoretical neuroscience we won't make much sense of anything.
What's neat about connectomics is that it provides a framework onto which map activity, resolve ambiguities in activity data without enough temporal resolution, and map receptors and neurotransmitters. It's also dense: complete, all neurons are there, independently of the idiosyncrasies of genetic driver lines.
The connectome of the Drosophila male nerve cord, where the neural circuits for generating the courtship song reside, has already been mapped:
"A Connectome of the Male Drosophila Ventral Nerve Cord", by Takemura et al. 2023
https://www.biorxiv.org/content/10.1101/2023.06.05.543757v1
What's missing now is the brain of the male. I'll let the joke write itself.
Whole adult fly brain connectome for FAFB (female adult fly brain) – last year in preprint form, today as an immersive feature in Nature.
140,000 neurons, over 50 million synapses – organised into over 8,000 cell types. (VNC not included.)
https://www.nature.com/immersive/d42859-024-00053-4/index.html
The whole connectome: Dorkenwald et al. 2024 (Seung, Murthy) https://www.nature.com/articles/s41586-024-07558-y
Cell types: Schlegel et al. 2024 (Jefferis) https://www.nature.com/articles/s41586-024-07686-5 by @uni_matrix
Network statistics: Lin et al. 2024 (Murthy) https://www.nature.com/articles/s41586-024-07968-y
Visual system: Garner et al. 2024 (Wernet, Kim) https://www.nature.com/articles/s41586-024-07967-z and Matsliah et al. (Murthy, Seung) https://www.nature.com/articles/s41586-024-07981-1
Seung also put out a solo paper on predicting visual function from the connectome: https://www.nature.com/articles/s41586-024-07953-5
Control of halting in walking: Sapkal et al. 2024 (Bidaye) https://www.nature.com/articles/s41586-024-07854-7
FAFB imaged by @davi 's group back in 2018: https://www.cell.com/cell/fulltext/S0092-8674(18)30787-6
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