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PLOS BiologyAntimicrobial resistance is a growing problem, ignored at our peril. In this <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> Perspective, Susanna Dunachie & Mariagrazia Pizza discuss the challenges raised by the lack of market incentives for new diagnostics, drugs and <a href="https://fediscience.org/tags/vaccines" class="mention hashtag" rel="nofollow noopener" target="_blank">#vaccines</a> to tackle <a href="https://fediscience.org/tags/AMR" class="mention hashtag" rel="nofollow noopener" target="_blank">#AMR</a> and some potential solutions. <a href="https://plos.io/41ImKu9" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/41ImKu9</a>

PLOS BiologyNew <a href="https://fediscience.org/tags/antiretroviral" class="mention hashtag" rel="nofollow noopener" target="_blank">#antiretroviral</a> alert! A new study in <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> reveals a novel long-acting deoxyadenosine analog, MK-8527, that displays potent antiretroviral activity and favorable preclinical pharmacokinetic and off-target profiles in non-human primate models of <a href="https://fediscience.org/tags/HIV" class="mention hashtag" rel="nofollow noopener" target="_blank">#HIV</a> infection. <a href="https://plos.io/45UfwV4" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/45UfwV4</a>

PLOS BiologyIn this <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> Consensus View, <a href="https://bird.makeup/users/neurofishh" class="u-url mention" rel="nofollow noopener" target="_blank">@neurofishh</a> <a href="https://bird.makeup/users/corbolab" class="u-url mention" rel="nofollow noopener" target="_blank">@corbolab</a> &co propose a new, consolidated, pan-vertebrate naming system for the rod and cone photoreceptors of the eye. <a href="https://plos.io/4m4QcTC" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/4m4QcTC</a>

PLOS BiologyVaccines are one of the greatest scientific success stories of our time. They have saved more than 154 million lives in the last 50 years — more than 1 life every 10 seconds.Recent moves to strip funding from vaccine-related research are shortsighted and self-harming. As is the use of precious resources to revisit debunked claims of links to autism.The best vaccine isn’t useful if it is not distributed, or not socially accepted. Vaccine equity and hesitancy remain great challenges. Globalizing antivaccine activism could become our greatest hurdle.It is not time to defund, but rather invest in vaccines.Read our latest editorial in <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a>: Vaccines work… and do not cause autism <a href="https://fediscience.org/tags/vaccines" class="mention hashtag" rel="nofollow noopener" target="_blank">#vaccines</a> <a href="https://fediscience.org/tags/vaccination" class="mention hashtag" rel="nofollow noopener" target="_blank">#vaccination</a> <a href="https://fediscience.org/tags/immunization" class="mention hashtag" rel="nofollow noopener" target="_blank">#immunization</a> <a href="https://fediscience.org/tags/WorldImmunizationWeek" class="mention hashtag" rel="nofollow noopener" target="_blank">#WorldImmunizationWeek</a> <a href="https://fediscience.org/tags/measles" class="mention hashtag" rel="nofollow noopener" target="_blank">#measles</a> <a href="https://fediscience.org/tags/outbreak" class="mention hashtag" rel="nofollow noopener" target="_blank">#outbreak</a> <a href="https://fediscience.org/tags/vaccinehesitancy" class="mention hashtag" rel="nofollow noopener" target="_blank">#vaccinehesitancy</a><a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003143" rel="nofollow noopener" translate="no" target="_blank">https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003143</a>

PLOS BiologySleep can support <a href="https://fediscience.org/tags/memory" class="mention hashtag" rel="nofollow noopener" target="_blank">#memory</a>, but can memory hyperfunction cause <a href="https://fediscience.org/tags/sleep" class="mention hashtag" rel="nofollow noopener" target="_blank">#sleep</a> deficits? They find that the short-sleep <a href="https://fediscience.org/tags/Drosophila" class="mention hashtag" rel="nofollow noopener" target="_blank">#Drosophila</a> mutant "<a href="https://fediscience.org/tags/insomniac" class="mention hashtag" rel="nofollow noopener" target="_blank">#insomniac</a>" has enhanced memory and that PKA signaling balances sleep & memory in these flies <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#plosbiology</a> <a href="https://plos.io/4ihHNtL" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/4ihHNtL</a>

PLOS BiologyNeural circuits that link genetic variation to <a href="https://fediscience.org/tags/behavior" class="mention hashtag" rel="nofollow noopener" target="_blank">#behavior</a>: This study of mate choice behavior in Heliconius cydno <a href="https://fediscience.org/tags/butterflies" class="mention hashtag" rel="nofollow noopener" target="_blank">#butterflies</a> shows that alterations to the peripheral nervous system, driven by genetic & gene expression differences, can alter essential behaviors <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#plosbiology</a> <a href="https://plos.io/4iHQDRd" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/4iHQDRd</a>

PLOS BiologyIntercellular interactions between DIP & Dpr proteins coordinate <a href="https://fediscience.org/tags/NeuralNetwork" class="mention hashtag" rel="nofollow noopener" target="_blank">#NeuralNetwork</a> assembly in flies, but what if they're expressed in the same cell? This study shows that DIPs & Dprs can interact in cis, & that the cis/trans balance plays a role in neural development <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#plosbiology</a> <a href="https://plos.io/3XpRs9f" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/3XpRs9f</a>

PLOS BiologyDynamics of a supergene. A study of the BC supergene in wing color morphs of the African monarch <a href="https://fediscience.org/tags/butterfly" class="mention hashtag" rel="nofollow noopener" target="_blank">#butterfly</a> by <a href="https://ecoevo.social/@rishidekayne" class="u-url mention" rel="nofollow noopener" target="_blank">@rishidekayne</a> &co reveals dynamic evolution of <a href="https://fediscience.org/tags/supergene" class="mention hashtag" rel="nofollow noopener" target="_blank">#supergene</a> haplotypes, fueled by incomplete recombination suppression <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#plosbiology</a> <a href="https://plos.io/3DiFhnL" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/3DiFhnL</a>

PLOS BiologyHow is the length of actin-based thin filaments in the human <a href="https://fediscience.org/tags/heart" class="mention hashtag" rel="nofollow noopener" target="_blank">#heart</a> maintained? This study shows that <a href="https://fediscience.org/tags/cardiac" class="mention hashtag" rel="nofollow noopener" target="_blank">#cardiac</a> leiomodin regulates the length of thin filaments by protecting newly formed units during systole & promoting <a href="https://fediscience.org/tags/actin" class="mention hashtag" rel="nofollow noopener" target="_blank">#actin</a> polymerization during diastole <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#plosbiology</a> <a href="https://plos.io/3CtG84I" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/3CtG84I</a>

PLOS BiologySensing food is a complex multisensory experience. A study of food hardness preference in <a href="https://fediscience.org/tags/FruitFly" class="mention hashtag" rel="nofollow noopener" target="_blank">#FruitFly</a> larvae by <a href="https://drosophila.social/@Simon_Sprecher" class="u-url mention" rel="nofollow noopener" target="_blank">@Simon_Sprecher</a> &co reveals that gustatory organ sensory neurons can perceive cues of both chemical & mechanical stimulation <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#plosbiology</a> <a href="https://plos.io/3CEv5FJ" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/3CEv5FJ</a>

PLOS BiologyA single stressful event can trigger long-term changes in behavior, but what initial events lead to these? This mouse study shows that acute <a href="https://fediscience.org/tags/stress" class="mention hashtag" rel="nofollow noopener" target="_blank">#stress</a> exposure modulates firing activity of PVT/CR+ neurons, which is key for long-term behavioral changes <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#plosbiology</a> <a href="https://plos.io/42pgGrE" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/42pgGrE</a>

PLOS BiologyMotion information is essential for processing visual information. This study shows that direction selectivity in later cortical stages inherits characteristics from earlier stages, further refined by intracortical connections <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> <a href="https://plos.io/40pt4X3" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/40pt4X3</a>

PLOS BiologyA previous study in <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#plosbiology</a> found that Wnt receptors are housed in early endosomes and required for dendritic <a href="https://fediscience.org/tags/microtubule" class="mention hashtag" rel="nofollow noopener" target="_blank">#microtubule</a> nucleation. This Update Article shows that microtubule dynamics in <a href="https://fediscience.org/tags/dendrites" class="mention hashtag" rel="nofollow noopener" target="_blank">#dendrites</a> can be influenced non-autonomously by surrounding epithelial cells plos.io/3DK0M0J

PLOS BiologyDo <a href="https://fediscience.org/tags/plants" class="mention hashtag" rel="nofollow noopener" target="_blank">#plants</a> with larger genomes grow faster under nutrient enrichment? Data from 27 nutrient addition experiments suggest that <a href="https://fediscience.org/tags/GenomeSize" class="mention hashtag" rel="nofollow noopener" target="_blank">#GenomeSize</a> improves predictions of species’ success in <a href="https://fediscience.org/tags/grassland" class="mention hashtag" rel="nofollow noopener" target="_blank">#grassland</a> communities @Jotosynthesis @E_HerschGreen &co <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> <a href="https://plos.io/4fi5dwS" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/4fi5dwS</a>

PLOS BiologyA computational modeling approach reveals how local changes in potassium concentration regulate dendritic integration of <a href="https://fediscience.org/tags/synaptic" class="mention hashtag" rel="nofollow noopener" target="_blank">#synaptic</a> inputs, revealing that 'potassium hotspots’ act as a gain control mechanism <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> <a href="https://plos.io/49rlAWo" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/49rlAWo</a>

PLOS BiologyHow does temperature affect <a href="https://fediscience.org/tags/sleeping" class="mention hashtag" rel="nofollow noopener" target="_blank">#sleeping</a> patterns? This study identifies neural circuits in flies that integrate temperature cues with <a href="https://fediscience.org/tags/circadian" class="mention hashtag" rel="nofollow noopener" target="_blank">#circadian</a> networks to modulate sleep-wake patterns <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3ZAgl3z" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/3ZAgl3z</a>

PLOS BiologyWhat causes <a href="https://fediscience.org/tags/itchy" class="mention hashtag" rel="nofollow noopener" target="_blank">#itchy</a> skin in old age? This study of aged mice shows that elevated release of vesicular Zn2+ from TMEM163+ <a href="https://fediscience.org/tags/neurons" class="mention hashtag" rel="nofollow noopener" target="_blank">#neurons</a> dampens activity of NPY neurons, so disinhibiting <a href="https://fediscience.org/tags/itch" class="mention hashtag" rel="nofollow noopener" target="_blank">#itch</a>-transmitting neural circuits, leading to <a href="https://fediscience.org/tags/ChronicItch" class="mention hashtag" rel="nofollow noopener" target="_blank">#ChronicItch</a> <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> <a href="https://plos.io/4g5HuRi" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/4g5HuRi</a>

PLOS BiologyDoes neuronal information storage involve nanoscopic structural changes at <a href="https://fediscience.org/tags/synapses" class="mention hashtag" rel="nofollow noopener" target="_blank">#synapses</a>? @olenas_kim &co use nanophysiology & functional EM to reveal structural changes of <a href="https://fediscience.org/tags/hippocampal" class="mention hashtag" rel="nofollow noopener" target="_blank">#hippocampal</a> <a href="https://fediscience.org/tags/ActiveZones" class="mention hashtag" rel="nofollow noopener" target="_blank">#ActiveZones</a> during chemical potentiation @ISTAustria <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3V22v7h" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/3V22v7h</a>

PLOS BiologyPrevious <a href="https://fediscience.org/tags/cryoEM" class="mention hashtag" rel="nofollow noopener" target="_blank">#cryoEM</a> of <a href="https://fediscience.org/tags/synucleinopathy" class="mention hashtag" rel="nofollow noopener" target="_blank">#synucleinopathy</a> α-synuclein fibrils revealed a ‘mystery density’ at the protofilament core. @jakob_lab &co now show that it's <a href="https://fediscience.org/tags/polyphosphate" class="mention hashtag" rel="nofollow noopener" target="_blank">#polyphosphate</a>, which binds a lysine-rich pocket & helps stabilize the fiber <a href="https://fediscience.org/tags/ParkinsonsDisease" class="mention hashtag" rel="nofollow noopener" target="_blank">#ParkinsonsDisease</a> <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3YP7Gdf" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/3YP7Gdf</a>

PLOS BiologyInfants have impressive <a href="https://fediscience.org/tags/auditory" class="mention hashtag" rel="nofollow noopener" target="_blank">#auditory</a> learning capabilities, even at day 1. Study shows that <a href="https://fediscience.org/tags/newborns" class="mention hashtag" rel="nofollow noopener" target="_blank">#newborns</a> & 6–mo-olds already learn & detect <a href="https://fediscience.org/tags/grammar" class="mention hashtag" rel="nofollow noopener" target="_blank">#grammar</a>-like rules; the underlying <a href="https://fediscience.org/tags/BrainNetworks" class="mention hashtag" rel="nofollow noopener" target="_blank">#BrainNetworks</a> reorganize to be more adult-like after the first half-year <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3UiaGMg" rel="nofollow noopener" translate="no" target="_blank">https://plos.io/3UiaGMg</a>

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