Job - Alert 
Postdoctoral fellow (m/f/d) – MF-2025-02
Deadline: 2025-04-27
Location: Germany, Regensburg, Bayern
#immunotherapy
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The March IHI newsletter is out - read it at https://europa.eu/!Hw6nXm 
Our director met with the European Parliament's Public Health Committee
Success stories from our projects on #Type1Diabetes, #COVID19 and #preparedness, & #immunotherapy 
Meet a new IHI #imaging project, and sign up for a webinar on our paediatric #cancer project ITCC-P4.
Last but not least - the deadlines for IHI calls 9 and 10 are approaching fast!
#IHITransformingHealth #HorizonEU #health #research #funding
RNA editing could be the key to fighting cancer and autoimmune diseases. Scientists at Rice just unlocked its secrets. Find out how!
Job - Alert
GROUP LEADER (M/F/D) – MF-2025-01
Deadline: 2025-04-13
Location: Germany, Regensburg, Bayern
Job - Alert
POSTDOCTORAL SCIENTIST (M/F/D)
Deadline: 2025-04-06
Location: Germany, Regensburg, Bayern
Not everyone responds well to #immunotherapy. 
New #tracers were developed by the Immune-Image project that can detect whether the body will reject the therapy or not, saving for #cancer patients & ensuring they get the right therapy, faster.
https://europa.eu/!NVF9fd
#HorizonEU #EUResearch
Small but very interesting: a new personalized T cell therapy in advanced metastatic #melanoma. Feasibility is demonstrated for this new #immunotherapy, but production time is
still around 19 weeks. Disease stabilisation is observed and immune responses could be measured.
#Oncology #Immunology #science #health
@chfloudas
https://www.nature.com/articles/s41591-024-03418-4
#ovariancancer has seen some progress in treatment options, but #immunotherapy remains a challenge. New data sheds light on the problems and raises the question: is checkpoint-inhibition the best strategy? Or do we maybe need a better biomarker to select patients for immunotherapy? #Oncology #science #health #medicine #gynecology #cancer @chfloudas
https://www.fiercepharma.com/pharma/mirroring-mercks-problem-gsks-jermperli-zejula-test-ovarian-cancer-misses-survival-goal
Lutz Nuhn @NuhnLab secures #ERCCoG Grant: Controlled Degradable Polymer Carriers for #mRNA #Vaccination: From Pathogens to Personalised #Cancer #Immunotherapy #PolymeRNA
https://nachrichten.idw-online.de/2024/12/03/chemistry-professor-lutz-nuhn-secures-erc-consolidator-grant
nachrichten.idw-online.deChemistry Professor Lutz Nuhn Secures ERC Consolidator Grant
Researchers from @uppsalauni and @OVGUpresse #Magdeburg obtain an @ERC_Research Synergy Grant to advance #cancer #immunotherapy. #ERCSyG
https://nachrichten.idw-online.de/2024/11/05/researchers-from-uppsala-and-magdeburg-obtain-an-erc-synergy-grant-to-advance-cancer-immunotherapy
nachrichten.idw-online.deResearchers from Uppsala and Magdeburg obtain an ERC Synergy Grant to advance cancer immunotherapy
Could mRNA vaccines be the next big thing for melanoma? #Immunotherapy #CancerImmunotherapy
https://theconversation.com/from-immunotherapy-to-mrna-vaccines-the-latest-science-on-melanoma-treatment-explained-231595?utm_medium=Social&utm_source=Facebook#Echobox=1717571145
The ConversationFrom immunotherapy to mRNA vaccines – the latest science on melanoma treatment explainedCould mRNA vaccines be the next big thing for melanoma?
Scientists Engineer Human T Cells 100x More Potent at Killing Cancer Cells
https://scitechdaily.com/scientists-engineer-human-t-cells-100x-more-potent-at-killing-cancer-cells/ #medicine #health #treatment #T—Cells #engineered #Cancer #Immunotherapy #tumours #nontoxic
SciTechDaily · Scientists Engineer Human T Cells 100x More Potent at Killing Cancer CellsResearchers have engineered T cells with a cancer-derived mutation, boosting their potency against tumors over 100-fold without toxicity, marking a significant advancement in immunotherapy that could extend its effectiveness to solid tumors. Current immunotherapies work only against cancers of
Interleukin-1 is involved in #inflammation but the role in #cancer is not so clear...and here is a new insight for #pancreaticcancer : a loop between tumour cells and interleukin-1β-expressing #tumor associated #macrophages is supporting the tumor, this being brought on by a synergy between prostaglandin E2 (PGE2) and tumour necrosis factor (TNF), also opening the door for translational interventions #immunotherapy #innateimmunity #Immunology @cyrilpedia @gpollara
NatureIL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer - NatureSingle-cell and spatial gene expression analyses of pancreatic ductal adenocarcinoma uncover a population of interleukin-1β-expressing macrophages that drive inflammatory reprogramming of neighboring tumour cells leading to disease progression and poor prognosis for patients.
A new tool to rapidly grow cancer-killing white #blood #cells could advance the availability of #immunotherapy, a promising therapy which harnesses the power of the body’s immune response to target #cancer cells.
#Engineering #Biology #Chemistry #Technology #sflorg
https://www.sflorg.com/2023/10/eng10162301_01233382890.html
www.sflorg.comMachine can quickly produce needed cells for cancer treatmentThe bioreactor uses centrifugal force to act on the growing cells
We wrote the Cancer Immunity Cycle in 2013- and the scientific framework continues to hold up to time. After a decade of immense progress for patients with #cancer #immunotherapy we are excited to publish a 10Y update, reflecting the complexity in the TME.
'A single intramuscular injection of Lenti-HPV-07 into mice bearing established HPV-induced tumors resulted in complete tumor eradication in 100% of the animals and was also effective against lung metastases.'
#TumorImmunology #Immunology #immunotherapy
Douguet et al @EmboMolMed
Continued thread
But as is typical for biology, it's more complicated than it appears on the surface. In the case of MSI (microsatellite instability), cancers that have high MSI actually respond better to immunotherapy (i.e., good for the patient). For example, see: https://www.mdanderson.org/cancerwise/what-is-microsatellite-instability-MSI.h00-159617067.html#:~:text=Immunotherapy%20increases%20the%20body%27s%20ability,doesn%27t%20recognize%20as%20normal.
MD Anderson Cancer CenterWhat is microsatellite instability?When you’re diagnosed with cancer, your doctor may refer to whether the cancer has microsatellite instability (MSI). Gastrointestinal medical oncologist and researcher Jason Willis, M.D., Ph.D., explains what this means and why cancers with high MSI tend to respond better to immunotherapy.
Personalized RNA #vaccines for #melanoma advance to phase III trials (in combination with anti-PD1).
My latest Clinical Pipeline column for @NatureMedicine #Immunology #Immunotherapy
https://www.nature.com/articles/d41591-023-00072-0
T cells burn out just a few hours after encountering cancer tumors - Enlarge / This microscopy image shows a cytotoxic T cell (blue) attacki... - https://arstechnica.com/?p=1959111 #immuneresponse #immunotherapy #science #t-ceels #health #cancer #tcells
Ars TechnicaT cells burn out just a few hours after encountering cancer tumorsWhy do T cells become exhausted within a few hours of bumping into cancer?
It's been awhile, and there are lots of new users on here, so time for another #introduction post.
I'm Benny from CT, USA. I'm a #CNC #ProductionManager. It's high-stress and I hate it. I've been happily married for 20 years to my wife who was recently diagnosed with #cancer. She has #RenalCellCarcinoma and is currently undergoing #immunotherapy.
We have an amazing #lesbian daughter who I enjoy going to see #LiveMusic with. Particularly #GratefulDead related bands.
Staunch #Ally