RIP Jamie Rae
A kind obituary for a decent man who achieved a great deal in his life
#hpv
2 posts2 participants0 posts today
Our study on HPV45, one of ~13 cancer-causing types of #HPV, is out in the International Journal of Cancer.
Compared to most other types, HPV45 disproportionately causes adenocarcinoma—a form of cervical cancer that often lacks easily detectable precursors.
Each HPV type is often treated as a monolith—a single genetic entity with a given risk. But within-type variation can also matter.
Spearheaded by Aimee Koestler of the Lisa Mirabello lab, our study shows that viral genetic variation within HPV45 can influence cancer outcomes.
The A1 sublineage of HPV45, most prevalent in sub-Saharan Africa, was used as a baseline. Compared to A1, precancer/cancer risk is higher for sublineages A2 and B1. The A2 sublineage elevates risk particularly for women of Asian ancestry, among whom it has increased prevalence.
At a finer level, we also identified SNPs in the HPV45 genome that are associated with precancer/cancer risk. One of these, T3556G, occurs in the genome region encoding both E2 and E4; causes amino changes in both; and results in higher stability of E2 than any other possible amino acid at its position.
Please see the study for more details, including the cataloguing of new sublineages and subclades in HPV45 and implications for prognosis.
Huge congratulations to the whole Mirabello lab, and to mentee Aimee Koestler for her first first-author paper on HPV! https://onlinelibrary.wiley.com/doi/10.1002/ijc.35464
#Bulgaria expands free #HPV #vaccination to include boys, and older girls: Physicians welcomed the #vaccination program expansion, calling it ‘an extremely important step’ to tackle #HPV, the most common sexually transmitted infection in the world. https://www.euractiv.com/section/health-consumers/news/bulgaria-expands-free-hpv-vaccination-to-include-boys-and-older-girls/?utm_source=mastodon&utm_medium=dlvr.it
Anlässlich der Europäischen Impfwoche vom 27. April bis 3. Mai 2025 informieren wir über Humane Papillomviren (#HPV) und die Schutzmöglichkeiten.
HPV betreffen alle Geschlechter und verlaufen meist unbemerkt. Doch manche Infektionen können Krebs verursachen – Jahre später.
Die gute Nachricht: Eine Impfung im Kindes- und Jugendalter kann die meisten HPV-bedingten Krebserkrankungen verhindern. Die #STIKO empfiehlt sie schon ab 9 Jahren.
Alle Informationen unter:
https://www.rki.de/hpv-impfung
Completely #unethical: Women excluded from life-saving vaccine
Women in #Scotland being left at risk of killer #cancer because of refusal to fund preventative #vaccine through #NHS
Females aged 26-45 are currently excluded from the #HPV vaccine which protects against #cervical cancer and genital warts even though it is offered to men in high-risk groups in the same age category.
https://www.thenational.scot/news/25029802.completely-unethical-women-excluded-life-saving-vaccine/
Here’s my ‘urgent argument’:
It’s a vaccine that PREVENTS CANCER. And not just any cancer but really awful, terrible cancers.
It’s a fucking miracle of modern science, FFS!
From: https://flipboard.com/@npr/health-930k6cv1z/-/a-An1O_uAES362L7puqeD7Ow%3Aa%3A3195441-%2F0
NPR - Lisa Doggett · An urgent argument for the HPV vaccine
Humane Papillomviren #HPV können Krebs verursachen.
Der heutige internationale #HPVAwarenessDay macht darauf aufmerksam, dass eine #Impfung vor HPV-bedingtem Krebs schützen kann.
Die Impfbereitschaft ist bislang unzureichend.
Die Impfung ist von der #STIKO für alle Kinder ab 9 Jahren empfohlen.
HPV viruses are the leading cause of cervical cancer, with 800 Czech women infected each year. Vaccination is the most effective protection for both girls and boys. Last year, a record 1.2 million women underwent cervical screening, helping to diagnose HPV infections in 4,500 cases. Let's raise awareness about HPV and protect our health! #HPV #Vaccination #Prevention #Health
Více informací najdete zde:
https://tiskovec.cz/clanky/hpv-viry-zpusobuji-rakovinu-ockovani-pred-ni-chrani-divky-i-chlapce?utm_source=mastodon_czech&utm_medium=social&utm_campaign=new_article
Tiskovec.czHPV viry způsobují rakovinu, očkování před ní chrání dívky i chlapceS lidskými papilomaviry (HPV) se během života setká až 80 % populace. Jsou nejvýznamnější příčinou vzniku rakoviny děložního čípku. Tou se podle NZIP každoročně nakazí 800 českých žen a zhruba 300 žen na tento zhoubný nádor zemře.
Kennedy once called the HPV vaccine “the most dangerous vaccine ever invented.”
A new CDC report adds to evidence that the HPV vaccine is preventing cervical cancer. Rates for precancerous lesions decreased ~80% among young women screened over a 14-yr period. https://www.statnews.com/2025/02/27/hpv-vaccine-prevents-cervical-cancer-women-cdc-report/ #press #HPV
STAT · CDC report adds to evidence that HPV vaccine is preventing cervical cancer in U.S. womenA new CDC report adds to evidence that the HPV vaccine, once called dangerous by HHS Secretary Robert F. Kennedy Jr., is preventing cervical cancer in young women.
Am 4. Februar ist #Weltkrebstag – ein Anlass, diesen Monat auf HPV-bedingten #Krebs bei Männern aufmerksam zu machen. #ZahldesMonats #HPV
Die #STIKO empfiehlt auch Jungen die HPV-Impfung. Doch in Deutschland sind erst rund ein Drittel der 15-jährigen Jungen vollständig geimpft. #Impfung
Zahlen und Fakten https://www.rki.de/zahldesmonats
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Sen #ElizabethWarren, Democrat of Massachusetts gets #RFKJr to say he will not take money from the drug industry. He pledges not to. Then she turned to his affiliation with a law firm that is suing Merck over its human papillomavirus #HPV #vaccine. Kennedy has said he is entitled to a 10% fee from that ongoing lawsuit; on his financial disclosure forms he said he would continue to receive those fees as secretary. [see #GiftArticle earlier in 
]
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The #ethics doc said #RFKJr would continue to collect fees for cases in which he referred clients to Wisner Baum, a law firm suing Merck over Gardasil, a #vaccine that protects against the human papillomavirus, or #HPV. The vaccine is administered to adolescents to prevent cervical & other #cancers later in life.
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…In Tuesday’s letter, she cited a NYT report that #RFKJr would keep his #financial stake in litigation against a manufacturer of a #vaccine that protects against… #HPV. The vaccine, which is administered to adolescents, can prevent cervical #cancer.
“In other words, he is willing to enrich himself by denying access to a vaccine that can prevent almost all forms of cervical cancer & which has been safely administered to millions of boys & girls,” #CarolineKennedy wrote.
https://www.nytimes.com/2025/01/22/us/politics/rfk-hpv-vaccine-merck.html
The New York Times · R.F.K. Jr. Would Keep Stake in HPV Vaccine Suit if Confirmed
[21:34] Annemarie (30) deed zelftest baarmoederhalskanker. 'Ik denk dat veel vrouwen zich niet bewust zijn van de risico’s'
Meer dan de helft van de vrouwen tussen de 30 en 34 jaar doet niet mee aan het bevolkingsonderzoek baarmoederhalskanker, terwijl in deze groep HPV het vaakst voorkomt. Een zelftest helpt de deelname omhoog te krijgen.
https://www.dvhn.nl/meer/gezond/Baarmoederhalskanker-helft-jonge-vrouwen-doet-niet-mee-29347777.html
#30 #34jaar #HPV
Dagblad van het Noorden · Annemarie (30) deed zelftest baarmoederhalskanker. 'Ik denk dat veel vrouwen zich niet bewust zijn van de risico’s'
Brasil está perto de alcançar a meta de vacinação contra o vírus HPV
A imunização é estratégia importante para prevenção de infecções e cânceres.
O Ministério da Saúde havia demonstrado preocupação com a queda da cobertura vacinal:
Para saber mais:
Após 10 anos no SUS, vacinação contra HPV ainda enfrenta desinformação e falta de conhecimento
Agência Brasil · Brasil está perto de alcançar a meta de vacinação contra o vírus HPVNo ano passado, quase 85% do público-alvo já tinha sido imunizado. A doença é o terceiro tumor mais incidente e a quarta maior causa de morte entre as mulheres brasileiras.
#HPV #vaccination: How the world can eliminate cervical #cancer https://ourworldindata.org/hpv-vaccination-world-can-eliminate-cervical-cancer
Our World in DataHPV vaccination: How the world can eliminate cervical cancerHPV vaccines offer a rare opportunity to effectively eliminate one type of cancer. By taking this opportunity, it’s possible to save hundreds of thousands of women each year.
[16:50] Stephen Donnelly receives Laura Brennan Award for roll out of HPV jab catch-up programme
Health Minister Stephen Donnelly has been honoured with the Laura Brennan Award 2024 in memory of the late campaigner who died from cervical cancer and championed the HPV vaccine.
https://www.independent.ie/irish-news/stephen-donnelly-receives-laura-brennan-award-for-roll-out-of-hpv-jab-catch-up-programme/a1830971553.html
#StephenDonnelly #2024 #HPV
Irish Independent · Stephen Donnelly receives Laura Brennan Award for roll out of HPV jab catch-up programme
Many wonder whether there’s a benefit to receiving the #HPV #vaccine past a certain age, like 45. Guidelines differ and have changed over time.
The “basic science” remains the same: vaccination will prevent new infections, no matter how old you are. But there have been reasons for an age limit that are important to understand. 1/8
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Cancer is a random byproduct (not goal) of #HPV.
HPV sets up shop in the basal cells of our skin and mucosal linings, like the cervix and throat. Normally this is no problem, but if things go wrong it can cause cancer years later.
See our review for more. 3/3 https://www.sciencedirect.com/science/article/pii/S2666679023000058